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Inhibition of TLR4 signaling by TAK242 exerts antifibrotic effects in Tsk1/+ mice. Six week-old Tsk1/+ mice received TAK242 (i.p.; 30 mg/kg) daily, sacrificed at 12 weeks of age, and dorsal skin was harvested for analysis. (A) H and E stain (dotted line indicate hypodermis). (B) Hypodermal thickness (means ± s.d. of five determinations/hpf from four or five mice/group). Bar = 200 μm. Student's t-test.
