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. 2018 Oct 23;9:2434. doi: 10.3389/fimmu.2018.02434

Figure 5.

Figure 5

Inhibition of TLR4 signaling by TAK242 ameliorates peritoneal fibrosis. C57/BL6 mice received i.p. injections of vehicle or chlorhexidine gluconate (CG) alone (i.p.; every other day), or together with TAK242 (daily PO, BID; 10 or 30 mg/kg) started concurrently with CG injections. Mice were sacrificed at day 22, and parietal peritoneal membranes were harvested for analysis. (A) Left panel, Masson's trichome stain. (a) vehicle, (b) CG treatment, (c) CG plus concurrent treatment of TAK242 (low dose, 30 mg/kg; PO, BID), or (d) TAK242 (high dose, 100 mg/kg; PO, BID). Representative images. Bar = 25 μm. (B) Submesothelial compact zone thickness. Results are means ± s.d. of five determinations/hpf from five mice/group. One-way analysis of variance followed by Sidak's multiple comparison test. (C) Real-time qPCR. Results, normalized with GAPDH, represent the means ± s.d. of triplicate determinations from at least four mice/group; One-way analysis of variance followed by Sidak's multiple comparison test.