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. 2018 Oct 23;9:2434. doi: 10.3389/fimmu.2018.02434

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Copyright © 2018 Bhattacharyya, Wang, Tamaki, Shi, Yeldandi, Tsukimi, Yamasaki and Varga.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TAK242 attenuates the activated SSc fibroblast phenotype. Confluent cultures of early-passage SSc skin fibroblasts were incubated in media with TAK242 (10 μM) or vehicle for 24 h. (A) Real-time qPCR. Results, normalized with GAPDH, are means ± s.d. compared to vehicle-treated controls. (B) Immunofluorescence using antibodies to type I collagen (red) and αSMA (green). Representative images. Bar = 50 μm. Inset, quantification of immunofluorescence. Quantification of fluorescence intensities using ImageJ (means from four randomly selected hpf from four SSc fibroblasts). Paired t-test. Each dot and color represent an individual.