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. 2018 Oct 30;5:180213. doi: 10.1038/sdata.2018.213

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Copyright © 2018, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files made available in this article.

PMC Copyright notice

Muscle biopsies were obtained in previously untrained male participants following 7-weeks of chronic resistance training (loading), 7-weeks exercise cessation/detraining (unloading) and a later 7-week period of chronic retraining (reloading). A biopsy was also obtained following the first acute (single) bout of resistance training (acute RE). The schematic shows the work-flow utilised to generate genome-wide DNA methylation profiles in human participants, the methodological approach and the assays utilised. Bioinformatical analysis was performed in Partek Genomic Suite (Partek Genomic Suite, V6.6, Missouri, USA). Schematic adapted from our primary paper¹⁶. Licensed under the Creative Commons Attribution 4.0 International Public License. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/legalcode.