Table 6.
Biomarkers of bone metabolism and subclinical inflammation
| Patients (A) | Control group 2 (B) | P-value (A,B) | Patients with splenectomy (a) | Patients without splenectomy (b) | P-value (a,b) | |
|---|---|---|---|---|---|---|
| Calcium (mmol/L) | 2.46 (2.36; 2.53) | 2.43 (2.34; 2.50) | 0.085 | 2.49 (2.36–2.56) | 2.45 (2.38–2.49) | 0.36 |
| Phosphate (mg/dL) | 3.8 (3.6; 4.2) | 3.9 (3.6; 4.1) | 0.897 | 4 (3.7–4.4) | 3.8 (3.5–4.2) | 0.447 |
| Total alkaline phosphatase (U/L) | 59 (49–68) | 63 (52; 80) | 0.056 | 69 (55–79) | 54 (45–62) | 0.002 |
| Parathormone intact (pg/mL) | 44.2 (35.8; 55.7) | 44.3 (36.9; 58.2) | 0.942 | 48.1 (33.9–60.1) | 44.2 (38.1–53.1) | 0.569 |
| 25-hydroxy-vitamin D (ng/mL) | 24.6 (18.8; 28.3) | 19.8 (17.6; 28.4) | 0.208 | 22.3 (18.4–26.2) | 24.6 (20.4–29.5) | 0.219 |
| OC (ng/mL) | 16.8 (13.1; 21.9) | 20.6 (17.3; 24.7) | 0.011 | 16.8 (13.8–24) | 16.8 (13.1–21.5) | 0.609 |
| P1NP (µL/L) | 59 (42; 73) | 56 (42; 76) | 0.886 | 65 (46–79) | 52 (42–63) | 0.135 |
| OPG (pmol/L) | 4.7±2.8 | 6.2±2.7 | 0.009 | 5.6±2.9 | 4.1±2.5 | 0.068 |
| Total soluble RANKL (pg/mL) | 49,250 (20,317; 1,06,000) | 54,910 (14,510–79,125) | 0.976 | 65,590 (23,200–99,500) | 46,950 (19,700–1,34,000) | 0.953 |
| C-terminal telopeptide of type 1 collagen (ß-CTX, ß-CrossLaps) (pg/mL) | 390 (273; 518) | 318 (256; 364) | 0.009 | 423 (240–518) | 390 (276–555) | 0.922 |
| Sclerostin (pmol/L) | 35 (29; 43) | 32 (27; 47) | 0.956 | 36 (32–46) | 34 (29–39) | 0.201 |
| hsCRP (mg/L) | 1.34 (0.49; 2.53) | 1.2 (0.5; 1.52) | 0.134 | 1.59 (0.74–2.53) | 1.09 (0.45–2.44) | 0.345 |
| IL-6 (pg/mL) | 2 (2–3) | 2 (2–2) | 0.008 | 2 (2–3) | 2 (2–2) | 0.7 |
| Iron (µg/dL) | 107.1±43.5 | 109.1±32.5 | 0.607 | 115 (90–147) | 93 (70–130) | 0.075 |
| Ferritin (ng/mL) | 251 (72; 476) | 36 (20; 106) | <0.001 | 252 (165–689) | 181 (44–383) | 0.13 |
| Transferrin (g/L) | 2.52 (2.27; 2.8) | 2.82 (2.49; 2.91) | 0.140 | 2.48 (2.31–2.79) | 2.55 (2.26–2.83) | 0.665 |
| Transferrin saturation (%) | 26.6 (22.5; 42.1) | 26.3 (23.3; 40.2) | 0.802 | 32.9 (24.9–44) | 23.9 (19.9–36.4) | 0.046 |
Note: Quantitative variables were expressed as means and standard deviations if they followed a normal distribution or as medians and quartiles otherwise. Bold values indicate statistically significant values, P<0.05.
Abbreviations: hsCRP, high-sensitive C-reactive protein; IL-6, interleukin-6; OC, osteocalcin; OPG, osteoprotegerin; P1NP, N-terminal propeptide of type 1 collagen.