Figure 4.

(A) pTau pathology (AT8 stain) pathognomonic of chronic traumatic encephalopathy (CTE) in the orbitofrontal frontal cortex of the left hemisphere of a patient with a single TBI occurred during childhood. (B) Perivascular pTau pathology, part of CTE pathology. (C)pTau pathology (AT8 stain) in the CA1 region of the left hippocampus typical of Alzheimer's disease (AD) pathology. The patient was never diagnosed with memory or other cognitive deficits until death. Based on the age of the patient, the presence of pTau pathology in the hippocampus is compatible with a diagnosis primary age‐related tauopathy (PART).