FIG. 9.

Key concepts connecting patient metabolic state and tumor redox state to tumor progression and response to treatment. Patients' diet and lifestyle underlie many aspects of HNSCC etiology by affecting energy metabolism and, therefore, genomic stability. At the same time, patient metabolic state affects tumor redox state, and together they drive tumor progression and response to treatment. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars