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Lyz-GRP78−/− mice are protected from obesity-mediated insulin resistance in skeletal muscle. A, B) Insulin action and glucose metabolism were measured during hyperinsulinemic-euglycemic clamp in WT and Lyz-GRP78−/− mice that were fed chow (A) and HFD (B) for 9 wk (n = 5–8/group). *P < 0.05 vs. HFD-fed WT mice.
