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. Author manuscript; available in PMC: 2018 Oct 30.
Published in final edited form as: Dev Cell. 2018 Feb 5;44(3):284–296. doi: 10.1016/j.devcel.2018.01.009

Figure 2. Cell Extrusion Coupled to Drosophila Neuroblast Division and Differentiation.

Figure 2.

Proper extrusion of Drosophila neuroblasts (NBs) enables asymmetric NB divisions, daughter cell fate decision, and correct neurogenesis. Bazooka (PAR3, Baz) localizes apically in the mother epithelium, a polarity that critically is inherited by extruding NBs. During NB delamination, Inscuteable (Insc) is expressed, localizes apically, and recruits Pins. During mitotic division, several proteins (including Numb) localize to the basal cortex. This correct, asymmetric segregation of key proteins governs daughter cell fates and generates a new neuroblast and a ganglion mother cell (GMC), which produces neurons and glia.