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. Author manuscript; available in PMC: 2019 Apr 9.
Published in final edited form as: Sci Signal. 2018 Oct 9;11(551):eaau0727. doi: 10.1126/scisignal.aau0727

Fig. 1. Loss of p38α signaling correlates with enhanced tumorigenesis in human barrier tissues.

Fig. 1.

(A to C) Differential survival rates of the indicated TCGA patient groups with high and low phosphorylated (p-) p38 signals in their tumors are shown as P values by log-rank test. The cancer types are indicated by TCGA abbreviations, including LUSC (lung squamous cell carcinoma) and ESCA (esophageal carcinoma). The survival of LUSC and ESCA patients (n = 160 and 63 per group, respectively) is shown in Kaplan-Meier plots (B and C).

(D and E) Human actinic keratinosis (AK) skin and SCC tumor sections (n = 10 and 16, respectively) were analyzed by immunostaining (D). Dotted line, the epidermal-dermal boundary (D). p-p38 signals were graded from 0 to 3 based on immunofluorescence (IF) intensity per cell (E). P values by Mann-Whitney test.