Table 3:
Serial Echocardiographic Indices of LV Function in Vehicle- and Metformin-Treated Swine.
| n= 10 per group | Heart Rate (bpm) | LAD EDWT (mm) | LAD ESWT (mm) | LAD WT (%) | Fractional Shortening (%) | LV Ejection Fraction (%) | |
|---|---|---|---|---|---|---|---|
| Baseline | Vehicle | 101±6 | 8.0±0.4 | 13.6±0.7 | 71±3 | 33±1 | 62±2 |
| Metformin | 99±6 | 8.5±0.4 | 14.4±0.8 | 70±3 | 35±2 | 65±2 | |
| P-value | 0.84 | 0.64 | 0.64 | 0.75 | 0.41 | 0.42 | |
| 1 Hour Post Reperfusion | Vehicle | 75±4 | 13.7±0.6 | 14.1±0.7 | 3±2 | 24±2 | 47±3 |
| Metformin | 69±3 | 13.7±0.8 | 14.3±0.9 | 4±1 | 27±2 | 50±5 | |
| P-value | 0.15 | 0.96 | 0.84 | 0.63 | 0.33 | 0.69 | |
| 1-Week Post Reperfusion | Vehicle | 88±5 | 9.4±1.0 | 10.2±1.3 | 9±4 | 28±2 | 53±3 |
| Metformin | 92±6 | 10.8±0.7 | 12.7±1.1 | 17±5 | 29±2 | 56±3 | |
| P-value | 0.63 | 0.25 | 0.19 | 0.27 | 0.58 | 0.58 |
Values are mean±SEM. LAD indicates region supplied by left anterior descending coronary artery; EDWT, end-diastolic wall thickness; ESWT, end-systolic wall thickness; WT, wall thickening; LV, left ventricular.