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. 2018 Oct 25;11:7493–7501. doi: 10.2147/OTT.S161852

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© 2018 Zhou et al. This work is published and licensed by Dove Medical Press Limited

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Overexpression of exogenous FAM129B upregulated the expression of MMP2 and cyclin D1 and promoted tumor invasion and proliferation of H460 cells.

Notes: (A) Western blotting showed that FAM129B was highly expressed in H1299 cells and A549 cells and weakly expressed in H460 cells. After overexpressing FAM129B in H460 cells (B), MMP2 and cyclin D1 were markedly elevated, whereas other proteins including MMP9, cyclin A2, cyclin B1 and cyclin E1 showed no visible changes (C). Matrigel assay (D and E, 400×, scale bar=50 µm), colony formation assay (F and G) and MTT (H) revealed that tumor invasion and proliferation were enhanced by overexpression of FAM129B. *P<0.05; **P<0.01.