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. 2018 Oct 25;11:7493–7501. doi: 10.2147/OTT.S161852

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© 2018 Zhou et al. This work is published and licensed by Dove Medical Press Limited

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Knockdown of endogenous FAM129B downregulated expression of MMP2 and cyclin D1 and inhibited tumor invasion and proliferation in A549 cells.

Notes: After depleting the expression of FAM129B (A), protein levels of MMP2 and cyclin D1 were prominently downregulated, while other proteins such as MMP9, cyclin A2, cyclin B1 and cyclin E1 showed no significant changes (B). Matrigel assay (C and D, 400×, scale bar=50 µm), colony formation assay (E and F) and MTT (G) revealed that tumor invasion and proliferation were enhanced by overexpression of FAM129B. *P<0.05; **P<0.01.

Abbreviation: NC, negative control.