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. 2018 Oct 25;11:7493–7501. doi: 10.2147/OTT.S161852

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© 2018 Zhou et al. This work is published and licensed by Dove Medical Press Limited

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FAM129B facilitated tumor invasion and proliferation by promoting the phosphorylation of FAK at Tyr 397 and Tyr 925.

Notes: The phosphorylation of FAK (Tyr 397 and Tyr 925) was increased after overexpression of FAM129B in H460 and was decreased following depleting FAM129B in A549 (A and B). The elevation of MMP2 and cyclin D1 protein levels induced by FAM129B overexpression was reversed by incorporating FAK inhibitor (PF562271; C). The upregulation of tumor invasion (D and E, 400×, scale bar=50 µm), colony formation (F and G) and proliferation (H) caused by FAM129B overexpression were also attenuated by FAK inhibitor incorporation. **P<0.01.

FAM129B facilitated tumor invasion and proliferation by promoting the phosphorylation of FAK at Tyr 397 and Tyr 925.

Notes: The phosphorylation of FAK (Tyr 397 and Tyr 925) was increased after overexpression of FAM129B in H460 and was decreased following depleting FAM129B in A549 (A and B). The elevation of MMP2 and cyclin D1 protein levels induced by FAM129B overexpression was reversed by incorporating FAK inhibitor (PF562271; C). The upregulation of tumor invasion (D and E, 400×, scale bar=50 µm), colony formation (F and G) and proliferation (H) caused by FAM129B overexpression were also attenuated by FAK inhibitor incorporation. **P<0.01.