Fig 1. Schematic overview of RAVEN toolbox version 2.0.
RAVEN was significantly enhanced for de novo draft model reconstruction by integrating knowledge from different sources (e.g. KEGG and MetaCyc). It has better import/export support to relevant formats, and especially improved compatibility with the COBRA Toolbox by resolving previously conflicting function names and providing a bi-directional model conversion function. As a MATLAB toolbox, RAVEN provides one unified environment for both model reconstruction and simulation analysis (e.g. FSEOF) and allows scripting for more flexible operations.