Skip to main content
. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Xenobiotica. 2017 Mar 10;48(3):219–231. doi: 10.1080/00498254.2017.1296208

Figure 3.

Figure 3.

Correlation of SSS fold-error and animal/human ratios of Fm E, or CLp as a percentage of liver blood flow for in vitro data with AO substrates (A and C) or in vivo data with UGT substrates reported by Deguchi et al. (B and D). (A) fold-error in SSS of CLint vs animal/human ratio of Fm,AO (inset, axes magnified), (B) fold-error in SSS of CLp vs animal/human ratio of Fm,UGT (inset, axes magnified), (C) fold-error in SSS of CLint vs animal/human ratio of E (inset, axes magnified), and (D) fold-error in SSS of CLp vs animal/human ratio of CLp as a percentage of liver blood flow (inset, axes magnified). Zaleplon (•), O6-benzylguanine (■), zoniporide (○), BIBX1382 (□), and SGX523 (*). UGT substrates are collectively represented by (▲).