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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Xenobiotica. 2017 Mar 10;48(3):219–231. doi: 10.1080/00498254.2017.1296208

Table 1.

Multispecies intrinsic clearance (CLint, mL/min/kg) of zaleplon, O6-benzylguanine, zoniporide, BIBX1382, and SGX523 in incubations with hepatic S9 (in the presence of NADPH).

Zaleplon O6-benzylguanine Zoniporide BIBX1382 SGX523
Human 5.8 ± 1.02 17.8 ± 1.94 17.9 ± 1.77 80.2 ± 9.61 7.1 ± 2.28
Mouse 24.4 ± 5.28 20.7 ± 7.10 332 ± 11.3 33.2 ± 7.10 39.4 ± 7.19
Rat 15.6 ± 3.05 8.3 ± 2.03 466 ± 27.0 30.7 ± 3.56 35.3 ± 6.39
Guinea Pig 14.2 ± 1.89 60.3 ± 4.29 79.9 ± 7.47 72.7 ± 4.05 42.4 ± 4.71
Cynomolgus Monkey 20.3 ± 2.45 42.5 ± 8.40 62.8 ± 8.34 181 ± 11.5 44.4 ± 5.60
Rhesus Monkey 15.0 ± 2.06 22.9 ± 3.98 30.2 ± 3.29 114 ± 7.46 29.6 ± 7.22
Minipig 5.55 ± 1.34 4.43 ± 1.44 23.4 ± 2.07 134 ± 5.69 25.4 ± 1.46

Data represent means of triplicate determinations from 2–3 experiments (± SD).