Skip to main content
. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Xenobiotica. 2017 Mar 10;48(3):219–231. doi: 10.1080/00498254.2017.1296208

Table 2.

Multispecies hepatic clearance (CLHEP, mL/min/kg) of zaleplon, O6-benzylguanine, zoniporide, BIBX1382, and SGX523 in incubations with hepatic S9 (in the presence of NADPH) and the estimated hepatic extraction ratio (E).

Zaleplon O6-benzylguanine Zoniporide BIBX1382 SGX523
CLHEP E CLHEP E CLHEP E CLHEP E CLHEP E
Human 4.55 ± 0.625 0.22 9.62 ± 0.593 0.46 9.64 ± 0.503 0.46 16.6 ± 0.417 0.79 5.22 ± 1.15 0.25
Mouse 19.0 ± 3.35 0.21 16.6 ± 4.51 0.18 70.8 ± 0.517 0.79 24.1 ± 3.85 0.27 27.2 ± 3.66 0.30
Rat 12.7 ± 2.10 0.18 7.40 ± 1.61 0.11 60.8 ± 0.485 0.87 21.3 ± 1.73 0.30 23.3 ± 2.85 0.33
Guinea Pig 11.5 ± 1.25 0.19 30.3 ± 1.11 0.50 34.5 ± 1.40 0.57 33.1 ± 0.838 0.54 24.9 ± 1.64 0.41
Cynomolgus Monkey 13.9 ± 1.16 0.32 21.4 ± 2.28 0.49 25.8 ± 1.43 0.59 35.4 ± 0.434 0.80 22.0 ± 1.39 0.50
Rhesus Monkey 11.2 ± 1.14 0.25 15.0 ± 1.75 0.34 17.9 ± 1.16 0.41 31.7 ± 0.593 0.72 17.5 ± 2.69 0.40
Minipig 4.60 ± 0.934 0.16 3.79 ± 1.04 0.14 12.7 ± 0.620 0.45 23.1 ± 0.170 0.83 13.3 ± 0.401 0.48

Data, calculated using CLint values from Table 1, represent means of triplicate determinations from 2–3 experiments (± SD).