Table 5.

Interspecies comparison of hepatic extraction ratio (E), fraction metabolized by AO (F_m,AO), and SSS predictions using in vitro CL_int (mL/min/kg) or in vivo CL_p (mL/min/kg) for zoniporide (top) and BIBX1382 (bottom).

Species	E^*	F_m,AO^#	S9 CL_int	SSS Human Predicted S9 CL_int	CL_p	SSS Human Predicted CL_p
Zoniporide
Human	0.46	0.72–0.77	17.9	---	21^§	---
Mouse	0.79	0.90	332	43.1	298^§	39.2
Rat	0.87	0.72–0.74	466	114	237^§	62.7
Cynomolgus Monkey	0.59	≥ 0.90	62.8	30.7	31^§	15.2
BIBX1382
Human	0.79	0.92	80.2	---	25–55^¶	---
Mouse	0.27	n/a	33.2	4.3	55^¶	7.2
Rat	0.30	≤ 0.69	30.7	7.5	55^¶	13.4
Cynomolgus Monkey	0.80	1.0	181	88.7	118^¶	56.0

Data from Table 2

Data from Table 3

^§

Obtained from: Dalvie D, Zhang C, Chen W, et al. (2010). Drug Metab Dispos 38:641–654.

^¶

Obtained from: Hutzler JM, Cerny MA, Yang YS et al. (2014). Drug Metab Dispos 42:1751–1760.