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. 2018 Oct 25;13:6855–6870. doi: 10.2147/IJN.S181928

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© 2018 Chen et al. This work is published and licensed by Dove Medical Press Limited

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Effect of nanoparticles on the CSC proportions in HepG2 cells, as reflected by tumor sphere formation ability.

Notes: (A) Representative images of tumor sphere formation in HepG2 cells. Bars represent 100 µm. (B) Measurement of tumor sphere formation in HepG2 cells. Data are presented as mean±standard deviation (n=3). ^*P<0.05; ^***P<0.001.

Abbreviations: CSC, cancer stem cell; DOX, doxorubicin; ELC, elacridar; NB, blank nanoparticle; ND, DOX-loaded nanoparticle; NDE, nanoparticles loaded with DOX and ELC at the optimized ratio; NE, ELC-loaded nanoparticle.