Figure 5. MDR-MTBC phylogeny and resistance mutations of isolates from Samara (Russia) and Karakalpakstan (Uzbekistan) Maximum likelihood tree (with 1,000 resamples, GTR nucleotide substitution model) based on 12,567 variable positions (SNPs) among 705 MDR-MTBC isolates from Karakalpakstan and Samara.

Any resistance associated mutations (see methods) for individual antibiotics are depicted with red bars for each isolate. The presence of any putative compensatory mutation in the RNA polymerase genes rpoA, rpoB, rpoC is depicted with green bars and country of origin and a genotypic pre-XDR and XDR isolate classification is color coded. PAS = para aminosalycylic acid.