Appendix 1—table 3. Mutations in rpoB, rpoA and rpoC associated with a putative compensatory effect in rifampicin resistant MTBC strains.

Data from 277 MDR-MTBC isolates from Karakalpakstan, Uzbekistan, stratified to the particularly successful variant termed Central Asian outbreak (CAO) and other Beijing isolates. Pairwise differences between the two groups calculated with Fisher exact test; two-tailed P-values are reported.

	Beijing CAO (n = 173)	Other Beijing (n = 64)	P-value	All (n = 277)
rpoB mutations outside RRDR, excluding codon 170,400,491 variants wild type	25 (14.5%) 147 (85.0%)	12 (18.8%) 52 (81.3%)	0.43	43 (15.5%) 234 (84.5%)
rpoC variants wild type	95 (54.9%) 78 (45.1%)	18 (28.1%) 46 (71.2%)	0.0002	126 (45.5%) 151 (54.5%)
rpoA variants wild type	5 (2.9%) 168 (97.1%)	2 (3.1%) 62 (96.9%)	1.00	7 (2.5%) 270 (97.5%)

Abbreviations: CAO = Central Asian outbreak, RRDR = rifampicin resistance determining region.