Appendix 1—table 3. Mutations in rpoB, rpoA and rpoC associated with a putative compensatory effect in rifampicin resistant MTBC strains.
Beijing CAO (n = 173) |
Other Beijing (n = 64) |
P-value | All (n = 277) |
|
---|---|---|---|---|
rpoB mutations outside RRDR, excluding codon 170,400,491 variants wild type |
25 (14.5%) 147 (85.0%) |
12 (18.8%) 52 (81.3%) |
0.43 | 43 (15.5%) 234 (84.5%) |
rpoC variants wild type |
95 (54.9%) 78 (45.1%) |
18 (28.1%) 46 (71.2%) |
0.0002 | 126 (45.5%) 151 (54.5%) |
rpoA variants wild type |
5 (2.9%) 168 (97.1%) |
2 (3.1%) 62 (96.9%) |
1.00 | 7 (2.5%) 270 (97.5%) |
Abbreviations: CAO = Central Asian outbreak, RRDR = rifampicin resistance determining region.