Table 1. Patient Characteristic, and characteristics stratified by the highest and lowest mast cell quartile, and by mast cell to eosinophil ratios ≤1 and >1.
| Characteristic | Overall EoE population n=96) |
Lowest mast cell quartile (n=24) | Highest mast cell quartile
(n=24) |
p | Mast cell to eos ratio ≤ 1 (n=72) | Mast cell to eos ratio > 1
(n=24) |
p |
|---|---|---|---|---|---|---|---|
| Mast cell density (mean cells/mm2 ± SD) |
266.8 ± 180.0 | 88.7 ± 32.6 | 515.3 ± 157.4 | -- | 235.1 ± 142.2 | 361.6 ± 242.6 | 0.002 |
| Eosinophil density (eos/mm2; mean ± SD) |
555.9 ± 478.1 | 304.2 ± 212.0 | 717.5 ± 501.1 | < 0.001 | 664.6 ± 498.8 | 229.8 ± 168.8 | < 0.001 |
| Age at diagnosis (mean ± SD) | 37.2 ± 12.7 | 38.0 ± 14.2 | 38.4 ± 13.6 | 0.91 | 37.1 ± 12.6 | 37.6 ± 13.2 | 0.88 |
| Male (n, %) | 54 (56) | 10 (42) | 15 (63) | 0.15 | 38 (53) | 16 (67) | 0.24 |
| White (n, %) | 91 (95) | 23 (96) | 24 (100) | 0.31 | 68 (94) | 23 (96) | 0.79 |
| Symptoms | |||||||
| Dysphagia (n, %) | 94 (98) | 24 (100) | 23 (96) | 0.31 | 71 (99) | 23 (96) | 0.41 |
| >5 yrs of dysphagia (n, %) | 53 (60) | 13 (56) | 12 (55) | 0.51 | 37 (57) | 16 (70) | 0.67 |
| VAS* score (mean ± SD | 3.5 ± 2.7 | 2.4 ± 1.9 | 3.6 ± 2.8 | 0.12 | 3.5 ± 2.6 | 3.5 ± 3.0 | 0.97 |
| Heartburn (n, %) | 8 (8) | 1 (4) | 2 (8) | 0.55 | 7 (10) | 1 (4) | 0.39 |
| GERD-Q† (mean ± SD) | 4.7 ± 6.3 | 2.6 ± 3.9 | 4.5 ± 5.6 | 0.19 | 4.2 ± 6.3 | 6.2 ± 6.3 | 0.21 |
| Abdominal pain (n, %) | 7 (7) | 0 (0) | 1 (4) | 0.31 | 5 (7) | 2 (8) | 0.82 |
| SODA‡ score (mean ± SD) | 42.8 ± 12.5 | 39.1 ± 11.7 | 42.3 ± 12.8 | 0.51 | 43.3 ± 12.1 | 41.1 ± 13.9 | 0.58 |
| Nausea/Vomiting (n, %) | 0 (0) | 0 (0) | 0 (0) | -- | 0 (0) | 0 (0) | -- |
| Any atopic disorder (n, %) | 69 (72) | 11 (46) | 16 (67) | 0.31 | 44 (61) | 15 (63) | 0.65 |
| Asthma | 30 (32) | 6 (25) | 8 (33) | 0.46 | 23 (32) | 7 (29) | 0.86 |
| Atopic dermatitis | 10 (11) | 2 (8) | 2 (8) | 0.93 | 6 (8) | 4 (17) | 0.24 |
| Allergic rhinitis/sinusitis | 62 (66) | 16 (67) | 14 (58) | 0.68 | 47 (65) | 15 (63) | 0.93 |
| Food allergies | 35 (37) | 7 (29) | 9 (38) | 0.41 | 26 (36) | 9 (38) | 0.84 |
| EGD findings (n, %) | |||||||
| Normal | 3 (3) | 1 (4) | 0 (0) | 0.31 | 2 (3) | 1 (4) | 0.74 |
| Rings | 84 (88) | 19 (79) | 22 (92) | 0.22 | 62 (86) | 22 (92) | 0.48 |
| Strictures | 37 (39) | 11 (46) | 6 (25) | 0.13 | 30 (42) | 7 (29) | 0.28 |
| Narrowing | 36 (38) | 7 (29) | 8 (33) | 0.76 | 29 (40) | 7 (29) | 0.33 |
| Crepe paper mucosa | 7 (7) | 1 (4) | 2 (8) | 0.55 | 7 (10) | 0 (0) | 0.11 |
| Furrows | 87 (91) | 20 (83) | 24 (100) | 0.04 | 66 (92) | 21 (88) | 0.54 |
| White plaques/exudates | 53 (55) | 11 (46) | 17 (71) | 0.08 | 45 (63) | 8 (33) | 0.01 |
| Edema/decreased vascularity | 51 (53) | 9 (38) | 14 (58) | 0.15 | 42 (58) | 9 (38) | 0.08 |
| Hiatal hernia | 12 (13) | 2 (8) | 0 (0) | 0.15 | 10 (14) | 2 (8) | 0.48 |
| Dilation performed | 34 (35) | 9 (38) | 6 (25) | 0.35 | 27 (38) | 7 (29) | 0.46 |
| Other histologic findings (n, %)# | |||||||
| Eosinophil degranulation | 86 (96) | 16 (84) | 24 (100) | 0.04 | 67 (99) | 19 (86) | 0.02 |
| Eosinophil microabscesses | 67 (74) | 13 (68) | 20 (83) | 0.25 | 59 (87) | 8 (36) | < 0.001 |
| Basal layer hyperplasia | 42 (49) | 7 (41) | 13 (54) | 0.41 | 36 (55) | 6 (29) | 0.03 |
| Spongiosis | 80 (89) | 14 (74) | 22 (92) | 0.11 | 61 (90) | 19 (86) | 0.67 |
| Lamina propria fibrosis | 22 (37) | 5 (36) | 5 (29) | 0.71 | 18 (43) | 4 (24) | 0.16 |
* VAS = visual analogue scale for dysphagia severity; data available for n = 79 overall, 42 in the quartile analysis, and 79 in the ratio analysis
† GERD-Q = Gastroesophageal reflux disease questionnaire; data available for 86 overall, 44 in the quartile analysis, and 86 in the ratio analysis
‡ Severity of Dyspepsia Assessment; data available for n = 54 overall, 27 in the quartile analysis, and 54 in the ratio analysis
# Data available for n = 90 overall, 43 in the quartile analysis, and 90 in the ratio analysis