Figure 6. Predicting the effects of copper toxicity using Model III.

A) Computational prediction of total cellular copper accumulation in P. aeruginosa WT strain for 4 mM (solid line) and 6 mM (dashed line) CuSO₄. B) Computational prediction of copper levels in the P. aeruginosa WT strain in the presence of 1 mM and 4 mM CuSO₄ in the periplasm (dashed line for 1 mM and dashed-dotted line for 4 mM) and for the cytoplasm (solid line for 1 mM and dotted line for 4 mM). C) Computational prediction of copper levels in the P. aeruginosa ΔcopA1 strain in the presence of 1 mM and 4 mM CuSO₄ in the periplasm (dashed line for 1 mM and dashed-dotted line for 4 mM) and for the cytoplasm (solid line for 1 mM and dotted line for 4 mM; note that the periplasm concentrations are very small).