Table 1.
Clinical gold standards for expected drug effects.
| Drug | Laboratory Measurement |
Knowledge- base derived gold standard |
Expert-curated gold standard |
|---|---|---|---|
| Allopurinol | Total Creatine Kinase | 1 | 0 |
| Allopurinol | Creatinine | 1 | 1 |
| Allopurinol | Potassium | 0 | 0 |
| Allopurinol | Hemoglobin | -1 | 0 |
| Amphotericin B | Total Creatine Kinase | 0 | 0 |
| Amphotericin B | Creatinine | 1 | 1 |
| Amphotericin B | Potassium | -1 | -1 |
| Amphotericin B | Hemoglobin | -1 | -1 |
| Furosemide | Total Creatine Kinase | 0 | 0 |
| Furosemide | Creatinine | 1 | 1 |
| Furosemide | Potassium | -1 | -1 |
| Furosemide | Hemoglobin | -1 | 1 |
| Ibuprofen | Total Creatine Kinase | 0 | 0 |
| Ibuprofen | Creatinine | 1 | 0 |
| Ibuprofen | Potassium | 1 | 0 |
| Ibuprofen | Hemoglobin | -1 | -1 |
| Simvastatin | Total Creatine Kinase | 1 | 1 |
| Simvastatin | Creatinine | 1 | 0 |
| Simvastatin | Potassium | 1 | 0 |
| Simvastatin | Hemoglobin | -1 | 0 |
| Spironolactone | Total Creatine Kinase | 0 | 0 |
| Spironolactone | Creatinine | 1 | 1 |
| Spironolactone | Potassium | 1 | 1 |
| Spironolactone | Hemoglobin | -1 | 1 |
| Warfarin | Total Creatine Kinase | 0 | 0 |
| Warfarin | Creatinine | 0 | 0 |
| Warfarin | Potassium | 0 | 0 |
| Warfarin | Hemoglobin | -1 | -1 |