Breg-like phenotype induction when B cells were treated with different virus isolates. B cells were treated for 48 h and analyzed by flow cytometry. (a) Average percentage of CD24hiCD38hiIL-10+, (b) CD24hiCD27+IL-10+ or (c) total IL-10-producing cells were analyzed in viable cells. The average+s.e.m. of nine experiments for mock and HIV-1NL4-3, six experiments for HIV-1-89.6, five experiments for HIV-1-Ba-L and HIV-1-LAI(BRU), and three experiments for T/F viruses (WITO, THRO, CH058 and CH077) are shown. *P<0.05 when comparing mock-treated condition versus HIV-treated conditions.