Table 1.
CD6 SNPs allele distribution in patients displaying ‘mild’ and ‘moderate-severe’ (top) or PASI scores ⩽7 and >7 (bottom)
| SNP | Allele | Mild Ps No. (%) | Moderate-severe Ps No. (%) | ORa (95% CI)b | P value | Adj.c ORa (95% CI)b | Adj. c P value |
|---|---|---|---|---|---|---|---|
| rs17824933 | C | 182 (80.5) | 271 (72.8) | ||||
| G | 44 (19.5) | 101 (27.2) | 1.54 (1.03–2.30) | 0.0343 | 1.44 (0.93–2.21) | 0.1009 | |
| rs11230563 | C | 110 (51.9) | 213 (60.5) | ||||
| T | 102 (48.1) | 139 (39.5) | 0.70 (0.50–0.99) | 0.0453 | 0.68 (0.47–0.99) | 0.0463 | |
| rs12360861 | G | 60 (28.6) | 70 (20.0) | ||||
| A | 150 (71.4) | 280 (80.0) | 0.63 (0.42–0.93) | 0.0206 | 0.68 (0.44–1.05) | 0.0811 |
| SNP | Allele | PASI⩽7 No. (%) | PASI>7 No. (%) | ORa (95% CI)b | P-value | Adj.c ORa (95% CI)b | Adj.cPvalue |
|---|---|---|---|---|---|---|---|
| rs17824933 | C | 226 (80.7) | 227 (71.4) | ||||
| G | 54 (19.3) | 91 (28.6) | 1.68 (1.14–2.46) | 0.0082 | 1.59 (1.05–2.42) | 0.0284 | |
| rs11230563 | C | 127 (49.2) | 196 (64.1) | ||||
| T | 131 (50.8) | 110 (35.9) | 0.54 (0.39–0.76) | 0.0004 | 0.53 (0.37–0.78) | 0.0010 | |
| rs12360861 | G | 75 (29.3) | 55 (18.1) | ||||
| A | 181 (70.7) | 249 (81.9) | 0.53 (0.36–0.79) | 0.0019 | 0.56 (0.36–0.85) | 0.0074 |
aOR=Odds Ratio
bCI=Confidence Interval
cAdj.=Adjusted; multivariate analysis adjusted by onset of disease, arthropathy occurrence, gender and disease length.