Table 2.
CD6 SNP genotypic frequency distribution among patients displaying ‘mild’ or ‘moderate—severe’ Ps (top) as well as low (⩽7) or high (>7) PASI scores (bottom)
| SNP | Genotype | Mild Ps, no. (%) | Moderate–severe Ps no. (%) | OR (95% CI) | P-value | Adj. a OR (95% CI) | Adj.a P-value |
|---|---|---|---|---|---|---|---|
| Rs17824933 | CC | 76 (67.3) | 97 (52.2) | ||||
| CG | 30 (26.5) | 76 (40.9) | 1.99 (1.18–3.33) | 0.009 | 1.78 (1.00–3.18) | 0.049 | |
| GG | 7 (6.2) | 13 (6.9) | 1.45 (0.55–3.83) | 0.447 | 1.25 (0.43–3.68) | 0.681 | |
| CG+GG | 37 (32.7) | 89 (47.8) | 1.88 (1.16–3.07) | 0.0103 | 1.68 (0.98–2.90) | 0.061 | |
| Rs11230563 | CC | 26 (24.5) | 72 (40.9) | ||||
| CT | 58 (54.7) | 69 (39.2) | 0.43 (0.24–0.76) | 0.0036 | 0.42 (0.22–0.80) | 0.008 | |
| TT | 22 (20.8) | 35 (19.9) | 0.57 (0.29–1.15) | 0.119 | 0.60 (0.27–1.32) | 0.203 | |
| CT+TT | 80 (75.5) | 104 (59.1) | 0.47 (0.28–0.80) | 0.0056 | 0.47 (0.26–085) | 0.013 | |
| Rs12360861 | GG | 51 (48.6) | 108 (61.7) | ||||
| AG | 48 (45.7) | 63 (36) | 0.32 (0.09–1.17) | 0.0834 | 0.42 (0.11–1.64) | 0.213 | |
| AA | 6 (5.7) | 4 (2.3) | 0.62 (0.38–1.02) | 0.0618 | 0.75 (0.43–1.30) | 0.304 | |
| AG+AA | 54 (51.4) | 67 (38.3) | 0.59 (0.36–0.96) | 0.0322 | 0.71 (0.41–1.22) | 0.211 |
| SNP | Genotype | PASI⩽7, no. (%) | PASI>7, no. (%) | OR (95% CI) | P-value | Adj. a OR (95% CI) | Adj. a P- value |
|---|---|---|---|---|---|---|---|
| Rs17824933 | CC | 93 (66.4) | 80 (50.3) | ||||
| CG | 40 (28.6) | 66 (41.5) | 1.92 (1.17–3.14) | 0.0097 | 1.88 (1.07–3.29) | 0.0288 | |
| GG | 7 (5.0) | 13 (8.2) | 2.16 (0.82–5.67) | 0.1185 | 1.85 (0.63–5.42) | 0.2622 | |
| CG+GG | 47 (33.6) | 79 (49.7) | 1.95 (1.22–3.12) | 0.0051 | 1.87 (1.10–3.20) | 0.0219 | |
| Rs11230563 | CC | 30 (23.3) | 68 (44.5) | ||||
| CT | 67 (51.9) | 60 (39.2) | 0.40 (0.23–0.69) | 0.0010 | 0.42 (0.23–0.78) | 0.0063 | |
| TT | 32 (24.8) | 25 (16.3) | 0.35 (0.18–0.68) | 0.0020 | 0.34 (0.16–0.74) | 0.0069 | |
| CT+TT | 99 (76.7) | 85 (55.6) | 0.38 (0.23–0.64) | 0.0002 | 0.40 (0.22–0.71) | 0.0020 | |
| Rs12360861 | GG | 60 (46.9) | 99 (65.1) | ||||
| AG | 60 (46.9) | 51 (33.6) | 0.15 (0.03–0.74) | 0.0194 | 0.22 (0.04–1.13) | 0.0694 | |
| AA | 8 (6.2) | 2 (1.3) | 0.52 (0.32–0.84) | 0.0082 | 0.56 (0.32–0.97) | 0.0377 | |
| AG+AA | 68 (53.1) | 53 (34.9) | 0.47 (0.29–0.77) | 0.00023 | 0.52 (0.30–0.89) | 0.0017 |
Abbreviations: Adj., adjusted; CI, confidence interval; OR, odds ratio; PASI, Psoriasis Area and Severity Index; SNP, single-nucleotide polymorphism.
aMultivariate analysis adjusted by onset of disease, arthropathy occurrence, gender and disease length.