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. 2018 Oct 24;10:37. doi: 10.3389/fnsyn.2018.00037

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Copyright © 2018 Brodin and Shupliakov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Retromer supports AMPA receptor trafficking during long-term potentiation (LTP). (A) Plot of the excitatory postsynaptic current (EPSC) amplitude during induction of LTP in control hippocampal slices (black dots) and hippocampal slices infected with lentivirus expressing an shRNA for VPS35 (green dots), and a further control, in which VPS35 expression had been restored (red dots). (B) Induction of chemical LTP causes incorporation of GluA1 receptors (tagged with a pH-sensitive reporter) in the dendritic plasma membrane of a hippocampal control neuron (left). The dendrite was photobleached prior to LTP induction to reveal the successive accumulation of GluA1 receptors. Knockdown of VPS35 (right) effectively inhibited receptor incorporation (reproduced from Temkin et al., 2017 with permission).