Table 1.

Main indications for complement diagnostics.

DEFICIENCIES OF COMPLEMENT COMPONENTS

Increased susceptibility to bacterial infections

Repeated severe (invasive) bacterial infections

Meningococcal disease

Autoimmune disease (SLE and related diseases)

HAE (C1-INH deficiency)

AAE (C1-INH deficiency)

DISEASE ACTIVITY AND DIFFERENTIAL DIAGNOSIS

SLE

Antiphospholipid syndrome

Urticarial vasculitis

Cryoglobulinemia

Various (RA, GPA, Henoch Schönlein)

C3 glomerulopathy and other types of glomerulonephritis

Thrombotic microangiopathies (aHUS)

Transplantation (AMR)

ASSESSMENT OF THERAPEUTIC EFFECTS

C1-INH

Eculizumab

SLE, systemic lupus erythematosus; HAE, hereditary angioedema,; AAE, acquired angioedema; C1-INH, C1 inhibitor; RA, rheumatoid arthritis; GPA, granulomatous polyangiitis; antibody mediated rejection; aHUS, atypical haemolytic uremic syndrome.