Table 3.
Examples of intracellular delivery of antibodies by nanocarriers.
| Nanocarrier | Antibody type | Targeted antigen | Reference |
|---|---|---|---|
| IgG-lipopolyamine dioctadecylglycylspermine complexes | IgG | β-actin, α-tubulin | Dalkara et al., 2004 |
| Cationic lipid-based complexes | mAb | HPV16 E6 oncoprotein | Courtete et al., 2007 |
| TAT-HA2 decorated gold nanoparticles | glycosylated mAbs | actin | Kumar et al., 2007, 2008 |
| Protein A Z-subdomain dimer fused with nucleocapsid protein incorporated into hemagglutinating virus of Japan envelope | IgG | α-tubulin nuclear pore complex | Kondo et al., 2008 |
| Gold-coated iron oxide nanoparticles or quantum dots decorated with Streptococcal bacterial protein G fused with TAT | mAb | mitochondria | Lim et al., 2009 |
| Polymersomes | IgG | – | Liu et al., 2010 |
| Polymersomes | IgG | NF-κB and γ-tubulin, actin, Golgi protein | Canton et al., 2013 |
| Self-associated MAb nanoparticles | mAb bevacizumab | VEGF | Srinivasan et al., 2013 |
| Self-assembling pyridylthiourea-modified polyethylenimine nanoparticles | mAbs modified with NLS | HPV-16 viral E6 oncoprotein, threonine-927 phosphorylation site of the EG5 kinesin spindle protein | Postupalenko et al., 2014 |
| Liposomes based on guanidinium-cholesterol cationic lipid BGTC combined to the colipid (DOPE) | mAb | cytokeratin8 | Chatin et al., 2015 |
| Polymersomes targeted to low density lipoprotein receptor-related protein 1 receptor | IgG | – | Tian et al., 2015 |
| Virus-like particles decorated with IgG binding moiety | IgG | abrin, anti-α-tubulin, HER2 | Abraham et al., 2016 |
| Mesoporous silica nanoparticles | chromobody: fluorescent nanobodies conjugated with fluorescent proteins or organic dyes | GFP | Chiu et al., 2016 |
| Polyion complex micelles | IgG Fc | nuclear pore complex | Kim A. et al., 2016 |
| Nanoparticles based on nanobodies with sequence-defined oligoaminoamides decorated with folic acid | nanobodies | GFP | Roder et al., 2017 |
| Calcium phosphate biomineralization | mAbs | Dengue virus surface envelope glycoprotein, Hemagglutinin (HA) protein of Influenza A virus | Song et al., 2016 |
| Erythrocyte membrane coated self-assembling nanoparticles | mAb | hTERT | Gao et al., 2017 |
| α-helical peptide Hex nanocarrier decorated with Aurein | IgG | anti-β-tubulin or anti-nuclear pore complex | Lim et al., 2017 |
| Oxidized carbon black particles | mAb | Dengue virus | Amornwachirabodee et al., 2018 |