. 2018 Oct 24;9:2465. doi: 10.3389/fimmu.2018.02465

Table 4.

Multivariate regression models to assess the association of post-vaccination HAI titres or post/pre-vaccination HAI titer ratios with Rockwood frailty score, age, gender and pre-vaccination HAI titres.

Dependent variable	Model statistics			Predictor variables
Model: Post/pre-vaccination HAI ratio ~ Rockwood frailty score + Age + Gender
	F	p	Adjusted R²	Age		Gender		Rockwood frailty score
				β	p	β	p	β	p
HAI, H1N1, Ratio (Day 28/Day 0)	0.699	0.553	−0.004	−0.023	0.484	−0.350	0.309	−0.486	0.831
HAI, H3N2, Ratio (Day 28 / Day 0)	1.079	0.359	0.001	−0.006	0.866	0.404	0.277	−3.046	0.214
HAI, B, Ratio (Day 28 / Day 0)	1.775	0.153	0.011	0.003	0.933	−0.383	0.255	–4.410	0.047
Model: Post-vaccination HAI ~ Rockwood frailty score + Age + Gender + Pre-vaccination HAI
Dependent variable	Model statistics			Predictor variables
	F	p	Adjusted R²	Age		Gender		Rockwood frailty score		HAI, Day 0
				β	p	β	p	β	p	β	p
HAI, H1N1, Day 28	15.04	9e-11	0.216	−0.017	0.553	−0.480	0.105	−0.348	0.858	0.463	3e-12
HAI, H3N2, Day 28	11.17	3.4e-8	0.166	0.038	0.142	−0.156	0.565	−2.976	0.093	0.310	4.7e-9
HAI, B, Day 28	6.91	3.1e-5	0.104	−0.007	0.728	−0.147	0.517	–2.833	0.061	0.241	1.9e-6
Model: Post/pre-vaccination HAI ratio ~ Rockwood frailty score + Age + Gender + Pre-vaccination HAI
Dependent variable	Model statistics			Predictor variables
	F	p	Adjusted R²	Age		Gender		Rockwood frailty score		HAI, Day 0
				β	P	β	p	β	p	β	p
HAI, H1N1, Ratio (Day 28 / Day 0)	19.37	2e-13	0.265	−0.017	0.553	−0.480	0.105	−0.348	0.858	–0.537	2e-15
HAI, H3N2, Ratio (Day 28 / Day 0)	48.08	2e-16	0.480	0.038	0.142	−0.156	0.565	−2.976	0.093	–0.690	2e-16
HAI, B, Ratio (Day 28 / Day 0)	62.41	2e-16	0.546	−0.007	0.728	−0.147	0.517	-2.833	0.061	-0.758	2e-16

Significant models and predictor variables are shown in bold. The titres were log₂ transformed.