Table 5.

Pre- and post-vaccination microneutralization (MN) titres across frailty strata.

Strain	MN responses	All (N = 205)	Frail (N = 59)	Pre-frail (N = 85)	Robust (N = 61)	p	p.adj
A/H1N1	Pre-vaccination (Day 0) MN titer, GMT	19 ± 5.9	16.8 ± 5.7	21.9 ± 5.7	17.5 ± 6.6	0.6174	0.974
	Post-vaccination (Day 28) MN titer, GMT	477.7 ± 6.3	511.3 ± 8.1	520.4 ± 5.5	397 ± 5.8	0.6453	0.974
	Post/Pre-vaccination MN ratio	25.2 ± 6.1	30.4 ± 7.8	23.7 ± 5.7	22.7 ± 5.1	0.6265	0.974
A/H3N2	Pre-vaccination (Day 0) MN titer, GMT	24.1 ± 3.8	23.3 ± 3.8	26.5 ± 3.7	21.7 ± 4	0.6510	0.974
	Post-vaccination (Day 28) MN titer, GMT	334.4 ± 3.8	339.8 ± 4	318.2 ± 3.9	352.8 ± 3.6	0.8941	0.974
	Post/Pre-vaccination MN ratio	13.9 ± 4.8	14.6 ± 4.1	12 ± 4.7	16.3 ± 5.6	0.4881	0.974
B	Pre-vaccination (Day 0) MN titer, GMT	44.6 ± 4.2	46.2 ± 4.2	42 ± 4.2	47 ± 4.5	0.8802	0.974
	Post-vaccination (Day 28) MN titer, GMT	680.3 ± 4.4	643.2 ± 4.7	707.5 ± 4.3	679.9 ± 4.3	0.9305	0.974
	Post/Pre-vaccination MN ratio	15.2 ± 5.2	13.9 ± 5.3	16.8 ± 4.9	14.5 ± 5.8	0.7644	0.974