Table 3.
Risk factors for final unfavorable outcomes (death or major neurological sequelae at discharge) by univariate and multivariate analysis.
| Parameters | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P-value | Adjusted OR (95% CI) | P-value | |
| Preterm birth (GA < 37 weeks) | 0.96 (0.38–2.46) | 0.933 | – | – |
| Seizure (within 3 days of meningitis onset) | 5.67 (2.22–14.45) | <0.001 | 4.76 (1.74–13.02) | 0.002 |
| Septic shock | 7.63 (1.98–29.36) | 0.003 | 6.04 (1.35–27.04) | 0.019 |
| Respiratory failure (with intubation) | 2.12 (0.88–6.61) | 0.095 | 0.84 (0.21–3.39) | 0.805 |
| Electrolyte imbalance | 2.36 (0.96–5.75) | 0.059 | 1.41 (0.50–3.97) | 0.516 |
| High protein level in CSF (> median [250 mg/dL]) | 0.96 (0.39–2.37) | 0.934 | – | – |
| Low glucose level in CSF (< median [30 mg/dL]) | 1.13 (0.46–2.76) | 0.797 | – | – |
| Group B Streptococcus | 1.50 (0.61–3.68) | 0.376 | – | – |
| Leukopenia (WBC count < 5,000 cells/uL) | 1.33 (0.53–3.36) | 0.543 | – | – |
| Anemia (hemoglobin level < 11.0 mg/dL) | 3.71 (1.48–9.26) | 0.005 | 1.55 (0.51–4.75) | 0.442 |
| Thrombocytopenia (platelet count < 150,000/uL) | 0.53 (0.17–1.55) | 0.242 | – | – |
GA, gestational age; CSF, cerebrospinal fluid; OR, odds ratio; 95% CI, 95% confidence interval.