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. 2018 Oct 24;5:86. doi: 10.3389/fmolb.2018.00086

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Copyright © 2018 Hervieu and Kermorgant.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PI3K activation by Met. (A) Table of PI3K isoforms and classes. Height PI3K isoforms divided into three classes depending on their lipid substrate, their catalytic subunit and their regulatory subunit. (B) Met, directly or indirectly, through adaptors, scaffolding molecules or other downstream signaling molecules, regulates class I PI3K activation. Dashed line: not demonstrated downstream of Met. Ptdlns(4,5)P2, phosphatidylinositol-4,5-bisphosphate; Ptdlns, phosphatidylinositol; Ptdlns4P, phosphatidylinositoi-4-phosphate; HGF, hepatocyte growth factor; PI3K, p110-p85; Grb2, growth factor receptor bound protein 2; She, Sarcoma (SRC) homology-2-containing; Gab1, Grb2-associated binding protein 1; SHP2, Src homology domain-containing 5′ inositol phosphatase 2; p120, p120-ras-GTPase activating protein; SOS, son of sevenless; FAK, focal adhesion kinase.