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. 2018 Oct 24;5:86. doi: 10.3389/fmolb.2018.00086

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Copyright © 2018 Hervieu and Kermorgant.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PI3K signaling activated by Met. Summary of Met/PI3K class I downstream signaling, that regulates migration, proliferation, apoptosis, protein translation and cell growth. Dashed line: not demonstrated downstream of Met. HGF, hepatocyte growth factor; PI3K, phosphatidylinositol 3-kinase; GTP, guanosine triphosphate; GSK3 beta, glycogen synthase kinase 3 beta; BAD, Bcl-2 antagonist of cell death; MDM2, mouse double minute 2 homolog; mTOR, mechanistic target of rapamycin; eiF, eukaryotic translation initiation factor; 4E-BP1, 4E–binding protein 1; FLIP, FLICE-like inhibitory protein; casp, caspase 3/8.