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. 2018 Oct 30;8:16012. doi: 10.1038/s41598-018-34394-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ITSCs differentiate into glutamatergic neurons after transplantation into ex vivo-cultivated murine organotypic hippocampal slices. (a) Schematic view showing experimental design of ITSC-transplantation into organotypic hippocampal slices. (b) Immunocytochemistry showing differentiation of ITSCs into MAP-2 and Gat-1 positive neurons, indicating successful integration of transplanted ITSCs into organotypic hippocampal slices. (d) Schematic view showing the transplantation procedure of GFP-positive ITSCs into organotypic hippocampal slices. E: GFP⁺-ITSCs integrated within the dentate gyrus of the hippocampus and exhibited a neuronal phenotype accompanied by expression of vGlut2 and Synaptophysin.