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. 2018 Oct 30;8:16012. doi: 10.1038/s41598-018-34394-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sex-specific response to oxidative stress insult and NF-κB-mediated neuroprotection in human NCSC-derived neurons. Female ITSC-derived neurons responded with a higher sensitivity to oxidative stress-induced neuronal death, and TNF-α-mediated neuroprotection compared to their male counterparts. TNF-α-mediated neuroprotection led to an increase in NF-κB-p65 nuclear translocation, triggering differential expression of sex-specific NF-κB target genes.