Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 30;9:4435. doi: 10.1038/s41467-018-06639-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Hypertrophy-stage-specific p53 signaling activation. a Bar plot showing the statistical significance of the overlap between modules detected from co-expression analysis with or without hypertrophy-stage cardiomyocytes. The most strongly overlapping module pairs are selected from Supplementary Fig. 13a. Modules are ordered by significance level. The red line indicates the threshold for hypertrophy stage-specific modules. b KEGG pathway enrichment of 12 hypertrophy stage-specific modules identified in a and Supplementary Fig. 13a. c Co-expression network analysis of M7. d Representative images of Cdkn1a mRNA smFISH in the heart from mice at 2 weeks after pressure overload. Wheat germ agglutinin (WGA) and DAPI are used as markers of the plasma membrane and nucleus, respectively. Scale bar, 20 μm. e Bar plots showing the distribution of cells corresponding to the single-cell fluorescent intensity of Cdkn1a mRNA detected by smFISH in the heart after sham and TAC (weeks 2 and 8) operation. f Heatmap showing the enrichment of GO and KEGG pathway terms in 12 hypertrophy stage-specific modules. g Immunohistochemical staining of gH2A.X and p21 in the heart of mice at 2 weeks after pressure overload. WGA and DAPI are used as markers of the plasma membrane and nucleus, respectively. Arrows indicate the nuclei of gH2A.X and p21 double-positive cardiomyocytes. Scale bar, 20 μm