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. 2018 Oct 30;8:16070. doi: 10.1038/s41598-018-34309-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time-dependent increases in apoptosis-related, nitroxidative stress marker and phosphorylated proteins following exposure to APAP-derived exosomes. (a) Immunoblot showing relative amounts of p-JNK/JNK, Bax, cleaved caspase-3 and β-actin, a loading control (n = 4/sample). (b and b) Caspase 3 and 9 activities (n = 8/sample). (d) Immunoblot showing relative amounts of nitroxidative stress markers, 3-NT, CYP2E1, and iNOS compared to β-actin and (e,f) phosphoproteins containing p-serine-proline (e) or p-threonine-proline (f) in primary hepatocytes treated with APAP-derived or CON-derived exosomes for 0, 2, 4, 8, and 24 h, as indicated (n = 4/sample). Full-length immunoblots are presented in Supplementary Figure 7.