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. 2018 Oct 30;8:16027. doi: 10.1038/s41598-018-34388-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Examples of the early phase (upper row) and late phase (lower row) of ¹⁸F-DTBZ PET images of a control (A), a patient with mild PD (B) and a patient with severe PD (C). Tracer uptake was retained in the bilateral caudate and left anterior putamen regions in mild PD (Hoehn and Yahr stage = 1), but was limited to a partial region of the caudate in severe PD (Hoehn and Yahr stage = 4). Colorbar scale represents as the SUR values. R:right side.