Table 3.
Test performance in comparison to BSI diagnosis according to the adapted ECDC criteria.
| BSI | BC | BAC BSI | SeptiFast | BC + BAC BSI | BC + SeptiFast | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| neg | pos | neg | pos | neg | pos | neg | pos | neg | pos | |
| neg | 115 | 9 | 119 | 5 | 124 | 0 | 111 | 13 | 115 | 9 |
| pos | 27 | 42 | 11 | 58 | 27 | 42 | 3 | 66 | 16 | 53 |
| ROC-AUC (95% CI) | 0.77 (0.70–0.83) | 0.90 (0.85–0.94) a | 0.80 (0.74–0.86) | 0.93 (0.88–0.96) b | 0.85 (0.79–0.90) c | |||||
| % sensitivity (95% CI) | 60.9 (48.4–72.4) | 84.1 (73.3–91.8) | 60.9 (48.4–72.4) | 95.7 (87.8–99.1) | 76.8 (65.1–86.1) | |||||
| % specificity (95% CI) | 92.7 (86.7–96.6) | 96.0 (90.8–98.7) | 100 (97.1–100) | 89.5 (82.7–94.3) | 92.7 (86.7–96.6) | |||||
| % PPV (95% CI) | 82.4 (70.8–90.0) | 92.1 (83.0–96.5) | 100 (−) | 83.5 (75.2–89.5) | 85.5 (75.6–91.8) | |||||
| % NPV (95% CI) | 81.0 (76.0–85.2) | 91.5 (86.3–94.9) | 82.1 (77.4–86.0) | 97.4 (92.4–99.1) | 87.8 (82.3–91.7) | |||||
BSI = bloodstream infection; ECDC = European Centre for Disease Prevention and Control; BC = blood culture; ROC-AUC = receiver operating characteristic-area under the curve; PPV = positive predictive value; NPV = negative predictive value; CI = confidence interval; aBAC BSI vs. BC: p = 0.004 and BAC BSI vs. SeptiFast: p = 0.034, bBC + BAC BSI vs. BC: p < 0.001 and BC + BAC BSI vs. BC + SeptiFast: p = 0.011, cBC + SeptiFast vs. BC: p < 0.001 as assessed by the Hanley & McNeil test.