Table 1.
Genotypes of Ehd1 mutant mice and mutant PC12 cells as well as other mutant mice generated by the CRISPR/Cas9 system.
| Genotypesa | Ehd1 | Ntrk1 | Chdh | Nlgn1 | |
|---|---|---|---|---|---|
| PC12 cellsb | Miceb | Mice | Mice | Mice | |
| WT/WT | 8 | 2 | 0 | 3 | 30 |
| WT/in-frame | 1 | 16 | 0 | 0 | 3 |
| WT/frameshift | 6 | 8 | 24 | 1 | 17 |
| in-frame/in-frame | 2 | 14 | 2 | 5 | 0 |
| in-frame/frameshift | 12 | 9 | 13 | 4 | 0 |
| frameshift/frameshift | 26 | 6 | 0 | 20 | 0 |
| Total | 55 | 55 | 39 | 33 | 50 |
| (frameshift/frameshift)/(in-frame/in-frame + in-frame/frameshift) | 1.85 | 0.26 | 0 | 2.22 | ND |
| IMPC | — | Incomplete | Lethal | Viable | ND |
aMice with other genotypes (knock-in, mosaic, etc.) are not shown in this table. bThe genotype distributions of the mice and PC12 cells are significantly different from each other (2 × 6 table, p < 5 × 10−8 by Fisher’s exact probability test). ND: not determined.