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. 2018 Oct 30;7:173. doi: 10.1038/s41426-018-0171-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Phylogenetic tree of the HCoV-OC43 strains based on whole-genome sequences. The tree was constructed by using the maximum likelihood (ML) method with the best-fit general time reversible model with gamma-distributed rate variation across sites and 1000 bootstrap replicates implemented in MEGA 5.03. Bootstrap values over 70% are shown in the nodes. b Estimation of pairwise genetic distances between genotype H and genotypes A–G of HCoV-OC43 strains based on the whole-genome sequences