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. 2018 Oct 30;8:15986. doi: 10.1038/s41598-018-33577-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Arrhythmia was induced after veratridine treatment in adult zebrafish. (A) Raw signal showing normal ECG before veratridine injection. (B) Significant first-degree AV block (prolonged PR interval) was observed within 5 minutes after veratridine (100 μM) was injected. (C) Heart rate, PR interval, QT interval and QTc interval before and after veratridine treatment. Data are presented as the mean ± SD, n = 10. **Indicates p < 0.001 as determined by paired t-test.