Table 3.

Multivariable analysis in all subjects regarding mammographic breast density in terms of overall survival.

Characteristics	HR	95% CI		p
Mammographic breast density, high vs low	0.382	0.206	0.708	0.002
Tumor size (cm), >2 vs ≤2	2.132	1.084	4.194	0.028
Nodal positivity, positive vs negative	1.103	0.605	2.013	0.749
Estrogen receptor, positive vs negative	0.757	0.391	1.469	0.411
Progesterone receptor, positive vs negative	0.612	0.313	1.196	0.151
HER2, positive vs negative	0.978	0.507	1.885	0.946
Histologic grade, 3 vs 1,2	1.406	0.793	2.492	0.243
Lymphovascular invasion, positive vs negative	2.525	1.315	4.851	0.005
Age (years), >50 vs ≤50	1.150	0.599	2.210	0.674
BMI (kg/m2), >25 vs ≤25	0.826	0.493	1.384	0.468
Operation, mastectomy vs lumpectomy	2.566	1.152	5.715	0.021
Radiation therapy, yes vs no	1.096	0.574	2.092	0.782
Chemotherapy, yes vs no	0.250	0.140	0.444	<0.001
Herceptin therapy, yes vs no	0.438	0.093	2.064	0.297
Endocrine therapy, yes vs no	1.227	0.563	2.673	0.607

Abbreviations: BMI, body mass index; CI, confidence interval; HR, hazard ratio.