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. 2018 Oct 30;9:4515. doi: 10.1038/s41467-018-06924-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — HDAC2^f/f CD4-Cre mice show enhanced colitis. Data shows a survival curve (%) (n = 12 per group), b percentage change in body weight, c FOB score, d diarrhea score, and e, f colon length of WT mice and HDAC2^f/f CD4-Cre mice (n = 6 per group) after intrarectal administration of 2.5% TNBS. g Real-time PCR and ELISA were used to analyze IL-17A expression in WT mice and HDAC2^f/f CD4-Cre mice given TNBS. h H&E-stained colonic sections and i disease scores of those sections are shown from WT mice and HDAC2^f/f CD4-Cre mice as in a–d (n = 4). Data are from one experiment representative of three independent experiments with similar results. *p < 0.05 and **p < 0.01 (two-tail t test) error bars are S.D.