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. 2018 Oct 30;8:15991. doi: 10.1038/s41598-018-34295-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Real-time in vivo imaging of cardiomyocytes and blood flow; and video-processing program. (a) Visualisation of regular motion of intercellular connections between adjacent cardiac myocytes and blood flow through capillaries and venules. Green, GFP; red, red-labelled dextran. Scale bar, 20 µm (Supplementary Video 2). (b) Analysis of the motion of normal cardiomyocytes facilitated by stabilisation of the beating heart by linear alignment and non-linear registration, followed by measurement of inter-pixel distance between reference points on a grid in the first frame and in each subsequent frame (Supplementary Video 3). Each image series (t₀–t₆) in Fig. 2 shows the movement over a period of approximately one heartbeat.