Figure 1.
PrEP drug concentrations in rectal secretions, rectal tissue and PBMC in study participants who took oral PrEP stratified by lubricant use.
TFV and FTC concentrations were measured by HPLC‐mass spectrometry and are presented in ng/swab for rectal secretions. Intracellular metabolites tenofovir‐diphosphate (TFV‐DP) and emtricitabine‐triphosphate (FTC‐TP) in biopsies and PBMCs were also measured by HPLC‐mass spectrometry and were normalized to concentrations per mg of tissue and per 106 cells respectively. All p‐values for median differences between study arms by Wilcoxon rank sum test >0.25. Drug levels below the limit of quantification are displayed at 10°. FTC, emtricitabine; PBMC, peripheral blood mononuclear cell; PrEP, pre‐exposure prophylaxis; TFV, tenofovir; TFV‐DP, tenofovir‐diphosphate.