FIGURE 3.

¹³C¹⁶O₂ production (Boudina and Abel, 2010) and O₂ consumption (MVO₂) (Veeranki et al., 2016) during oxidation of [1-¹³C] pyruvate by heart mitochondria from control and diabetic rats. (A) ¹³C¹⁶O₂ production and MVO₂ after addition of ADP. (B) ¹³C¹⁶O₂ production and MVO2 after addition of FCCP to uncouple oxidative phosphorylation. Both the ¹³C¹⁶O₂ production and MVO₂ stimulated by ADP FCCP were much less in DM mitochondria compared to Con. Data reprinted by permission from Nature/Springer/Palgrave: Doliba et al. (1997). Copyright 1997 by Springer Nature; License Number 4385511236859. Originally published by Plenum Press, New York 1997 (DOI 10987654321).